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In conclusion, chemical product manufacturers are an integral part of modern society. Their contributions span numerous industries and touch every aspect of our lives. From healthcare and agriculture to household goods and technological advancements, these companies continue to drive progress and improve our quality of life. As we move forward into an increasingly complex world, their role will only become more critical, underscoring the importance of continued investment and innovation within the chemical industry.

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Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

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