Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation. 

Titanium dioxide prices climbed significantly in the European region during Q2 2021, owing to strong demand from the downstream sector. Major global suppliers indicated that they have seen a surge in its demand for primarily from Europe and Asia, despite a global supply constraint. Furthermore, a global player raised titanium dioxide costs in Europe by 200 USD /MT this quarter, effective Q3 2021.