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Both P25TiO2NPs (with or without vitamin B2) were not found beyond the epidermis in 99% of the analyzed TEM images (Fig. 8). This is coherent with previous findings showing that nanoparticles greater than 50 nm can not penetrate the skin, even in vivo models with movement, stretching, and friction [54]. However, in one of the zones, a few nanoparticles were observed inside a hair follicle. This could be due to the follicle exposure after the localized rupture of this physical barrier when rats were shaved in order to clean the area for cream topical administration. This finding suggests that nanoparticle-based sunscreen should not be applied on recently shaved or harmed skin, in order to avoid nanoparticle skin penetration.

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In recent years, there has been a growing focus on sustainability and environmental responsibility in the manufacturing industry. Titanium dioxide manufacturers are no exception, with many companies implementing eco-friendly practices to minimize their impact on the environment. This includes reducing energy consumption, implementing recycling programs, and exploring alternative production methods that are more environmentally friendly.


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{随机栏目} 2025-08-15 05:39 1962