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The toxicity of P25TiO2NPs was evaluated in both prokaryotic (Fig. 3) and eukaryotic cells (Fig. 4). The XTT assay was chosen to measure the cell viability in bacterial cultures of MSSA, a normal skin microbiota microorganism. The reduction in the viability of samples with bare NPs is notorious, possibly due to the described ROS production from the interaction of P25TiO2NPs with light [37]. This effect seems to be avoided when they are functionalized with vitamin B2. Also, the most concentrated vitaminB2@P25TiO2NPs sample (0.2 mg/mL) shows up to 60% more absorbance after 6 h compared to the bare NPs (due to normal cell replication). This may indicate that the antioxidant effect of the vitamin B2 coating is greater than the oxidation damage produced by the NPs. This protective capacity could be attributed to the glutathione redox cycle and the conversion of reduced riboflavin to its oxidized form [38]. Values of cell viability greater than 100% are not rare and could be understood because the XTT assay actually measure metabolic activity when reducing the tetrazole to formazan. It is usually assumed that conversion is dependent on the number of viable cells, but it could also be related to an expected increased enzymatic activity when cells are exposed to small doses of some new substance. Further analysis showed that this effect was not the only one responsible for better cell viability of vitaminB@P25TiO2NPs treated samples.

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Moreover, NIOSH has also delved into the emerging field of nanotechnology, where TiO2 nanoparticles find applications in sunscreens, self-cleaning surfaces, and air purification systems. These nanoparticles can have different toxicological properties than their bulk counterparts, necessitating a more nuanced approach to risk assessment These nanoparticles can have different toxicological properties than their bulk counterparts, necessitating a more nuanced approach to risk assessment These nanoparticles can have different toxicological properties than their bulk counterparts, necessitating a more nuanced approach to risk assessment These nanoparticles can have different toxicological properties than their bulk counterparts, necessitating a more nuanced approach to risk assessmentniosh titanium dioxide. NIOSH has published guidelines and hazard evaluations to address potential exposure risks and promote safe handling practices.

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At our manufacturing facility, we are committed to sustainability and environmental responsibility. We take great care to ensure that our production processes are as environmentally friendly as possible, and we are constantly looking for ways to reduce our carbon footprint. By choosing our nano titanium dioxide products, customers can be confident that they are supporting a company that is dedicated to preserving the planet for future generations.


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