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It should also be considered that due to the low pH in the stomach, the increased dissolution of the TiO2 particles may increase its bioavailability and may facilitate the entry of titanium ions into the blood circulation. Despite the relatively large consumption of TiO2 as a food additive, no studies on the effect of pH on its absorption and bioavailability have been found in the literature. This can be attributed to a general belief that TiO2is completely insoluble. However, this is not completely true, as TiO2 particles show a certain degree of solubility.

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Raw material costs, particularly the price of titanium ore, have a significant impact on the price of titanium dioxide. As the cost of titanium ore rises, manufacturers may pass on these increased costs to consumers, leading to higher prices for titanium dioxide. Additionally, production capacity can also affect the price per ton. When there is excess capacity, manufacturers may compete for market share by lowering prices, which can lead to lower prices for consumers.

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