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Titanium dioxide, also known as TiO2, is a widely used pigment and catalyst in various industries. It's renowned for its exceptional brightness, high refractive index, and excellent chemical stability. Due to these properties, TiO2 has found extensive applications in paints, plastics, papers, inks, food colorants, sunscreens, and more. As demand for this versatile material grows, understanding the landscape of TiO2 manufacturers becomes increasingly important.

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In conclusion, titanium dioxide is a versatile and widely used chemical compound with a range of applications in various industries. Its excellent whiteness, opacity, chemical stability, and cost-effectiveness make it an attractive option for manufacturers looking for high-quality, durable products. As demand for titanium dioxide continues to grow, it is likely that we will see even more innovative uses for this versatile compound in the future.

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Duan et al. administered 125 mg/kg BW or 250 mg/kg BW of anatase TiO2 (5 nm) intragastrically to mice continuously for 30 days. The exposed mice lost body weight, whereas the relative liver, kidney, spleen and thymus weights increased. Particles seriously affected the haemostasis of the blood and the immune system. The decrease in the immune response could be the result of damage to the spleen, which is the largest immune organ in animals and plays an important role in the immune response. Powel et al. demonstrated that TiO2 NPs may trigger immune reactions of the intestine after oral intake. They showed that TiO2 NPs conjugated with bacterial lipopolysaccharide, but not TiO2 NPs or lipopolysaccharide alone, trigger the immune response in human peripheral blood mononuclear cells and in isolated intestinal tissue. This indicates that TiO2 NPs may be important mediators in overcoming normal gut-cell hyporesponsiveness to endogenous luminal molecules, which may be particularly relevant to patients with inflammatory bowel disease, which is characterized by an abnormal intestinal permeability.

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