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In the vast landscape of chemical manufacturing, few names resonate with the same level of innovation and quality as Sachtleben. Known for their meticulous approach to production, Sachtleben has established itself as a leading titanium dioxide (TiO2) manufacturer under its TIO2 brand. Titanium dioxide, often recognized for its superior pigmenting properties, is widely used in industries ranging from paints and coatings to plastics and paper.

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A study published in the Journal of Agricultural and Food Chemistry in 2019 sought to examine the effects of titanium dioxide on intestinal inflammation. Researchers did this by feeding rats titanium dioxide nanoparticles and found that, after the course of two to three months, the animals had lower body weights and induced intestinal inflammation. The researchers also found the nanoparticles altered gut microbiota composition and aggravated chronic colitis. The rats also experienced reduced populations of CD4+T cells (which are cells that help organize immune responses by prompting other immune cells to fight infection), regulatory T cells, and white blood cells in mesenteric lymph nodes. The researchers wrote: “Dietary TiO2 nanoparticles could interfere with the balance of the immune system and dynamic of gut microbiome, which may result in low-grade intestinal inflammation and aggravated immunological response to external stimulus, thus introducing potential health risk.”

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