2. Relative density: 4.136 to 4.39 g/mL.


What titanium dioxide is really emblematic of ... is the failure of FDA to look back at these old decisions and ask whether its decisions that were made in this case ... 56 years ago (in the 1966 approval) still hold up, he said.
Titanium dioxide is a mineral that’s used as a white coloring in a variety of products, including sunscreens, cosmetics, paints, and plastics. The pigment grade is also known as titanium white, pigment white 6, or CI 77891; it's the whitest and brightest of all known pigments.
The FDA has not updated its general guidance on safety assessments since 2007. Within that time, there has been a significant increase in research on the confluence of toxicology, nanotechnology and human health. The EU updates its guidance regularly with new science available to offer proper safety assessments, with its most recent update published in 2021.
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1. Sheet iron method
To be added to food, this additive must achieve 99% purity. However, this leaves room for small amounts of potential contaminants like lead, arsenic, or mercury (1Trusted Source).
Titanium dioxide comes in the form of a white powder and is sometimes used in cosmetics to adjust a color to a lighter shade. This is also why it can produce a white cast.
In food products, E171 is not a singular ingredient; it’s always combined with other ingredients (e.g., proteins and fats) in the food product. Digesting food is a slow process for the body compared to drinking a beverage, which passes much faster through the body.
Prof Matthew Wright, both a member of the FAF Panel and chair of EFSA’s working group on E 171, said: “Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive.”
2. Relative density: 4.136 to 4.39 g/mL.
But that depends on how titanium dioxide is being used and how you might come into contact with it. The International Agency for Research on Cancer (IARC) has classified titanium dioxide as possibly carcinogenic to humans based on studies that showed more lung tumors in rats associated with breathing in titanium dioxide.