The major restraint to the global Lithopone market is the availability of numerous white pigment substitutes. It can be replaced by other inorganic white pigments such as Titanium Dioxide (TiO2) and Sachtolith. Among these substitutes, the introduction of TiO2 has reduced the commercial importance of Lithopone white pigment. Compared to other white pigments, TiO2 has high brightness and refractive index, which results in lower pigment loading. 

Titanium dioxide is an important chemical compound that is widely used in various applications, including paint, cosmetics, sunscreens, and food coloring. As the demand for this versatile substance continues to grow, the role of titanium dioxide manufacturers becomes crucial in ensuring a stable supply for industries around the world.