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The most significant uncertainty identified by the EU experts was the concern that TiO2 particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO2 particles in E171 are genotoxic, they could not rule out the concern that they might be.

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Lithopone B301 is a synthetic pigment composed of a blend of zinc sulfide and barium sulfate. This unique combination offers several advantages over other pigments, such as high opacity, excellent hiding power, and good stability under various conditions. These qualities make it particularly useful in producing high-quality paints, plastics, and other products where consistent color and durability are paramount.

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