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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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4. DuPont DuPont is a global science and technology company that produces a wide range of products, including TiO2. The company operates several production facilities worldwide and offers a variety of TiO2 products, including rutile, anatase, and speciality grades. DuPont is known for its commitment to innovation and sustainability and continuously invests in research and development to improve the performance and environmental profile of its TiO2 products.

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