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No acute effects of nano-sized TiO2 were observed in Danio rerio (zebrafish) embryos. Exposure of rainbow trout to TiO2 NPs triggered lipid peroxidation, influence on the respiratory tract, disturbance in the metabolism of Cu and Zn, induction of intestinal erosion  and accumulation in kidney tissue. Linhua et al. exposed juvenile carp to 100 and 200 mg/ml of particles and TiO2 observed no mortality. However, the fish suffered from oxidative stress and pathological changes in gill and liver. In the infaunal species Arenicola marina, exposure to TiO2 NPs in sediment caused sub-lethal effects including decrease in casting rate and increase in cellular and DNA damage. Aggregated particles were visible in the lumen of the gut, but no uptake through the gut or the skin was observed.

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In conclusion, the market for titanium dioxide is evolving towards a greater emphasis on sustainability and value. Eco-friendly TiO2 suppliers who balance the best price with environmental responsibility and product quality are poised to lead the industry. As consumer awareness grows regarding the importance of sustainable materials, partnerships with such suppliers will become increasingly vital for businesses looking to maintain a competitive edge and a clean conscience.

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As the demand for titanium dioxide continues to grow, so does the competition among suppliers. Companies that can produce high-quality rutile and anatase titanium dioxide at competitive prices will likely gain a significant advantage in the market. Additionally, the development of new technologies for producing titanium dioxide, such as using biomass as a raw material or implementing more sustainable production methods, could further differentiate suppliers and drive innovation in the industry.

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