micronized tio2

Ponceau 4R, also known as Red No. 40, is a synthetic azo dye that is commonly used as a food coloring. It has a bright red color and is approved for use in the United States, Canada, and the European Union. In the cosmetics industry, Ponceau 4R is used as a colorant to add vibrant hues to lipsticks, blushes, eyeshadows, and other makeup products. It is known for its stability and compatibility with other ingredients, making it a popular choice among manufacturers.

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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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