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A  2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

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Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive, commented Matthew Wright, member of the EFSA's Food Additives and Flavourings Panel in a press statement.

We know that there are a lot of suspended organisms and colloidal impurities in natural water. The forms of suspended solids are different. Some large particles of suspended solids can settle under their own gravity. The other is colloidal particles, which is an important reason for the turbidity of water. Colloidal particles can not be removed by natural settlement, because colloidal particles in water are mainly clay with negative electricity The Brownian motion of colloidal particles and the hydration on the surface of colloidal particles make colloidal particles have dispersion stability. Among them, electrostatic repulsion has the greatest influence. If coagulant is added to water, it can provide a large number of positive ions and accelerate the coagulation and precipitation of colloid. Compressing the diffusion layer of micelles makes the potential change into an unstable factor, which is also conducive to the adsorption and condensation of micelles. The water molecules in the hydrated film have fixed contact with the colloidal particles and have high elastic viscosity. It is necessary to overcome the special resistance to expel these water molecules. This resistance hinders the direct contact of the colloidal particles. The existence of some hydrated films depends on the electric double layer state. If coagulant is added to reduce the zeta potential, the hydration may be weakened. The polymer materials formed after coagulant hydrolysis (the polymer materials directly added into water generally have chain structure) play an adsorption bridging role between the colloidal particles. Even if the zeta potential does not decrease or does not decrease much, the colloidal particles can not contact each other and can be adsorbed through the polymer chain Colloidal particles can also form flocs.