The concern from animal studies is that high amounts of titanium dioxide have increased inflammation and colon tumor formation, said Dr. Johnson-Arbor. A 2021 review, meanwhile, suggested that using titanium dioxide as a food additive weakens the gut lining and worsens the progression of inflammatory bowel disease.

EFSA Scientific Conclusion on E171

Because of their small size, nanoparticles may have unique physical and chemical properties. These properties may cause them to interact with living systems differently than larger materials with the same chemical composition (also known as bulk materials).

About Titanium Dioxide. Titanium Dioxide, a white crystalline powder, represents the natural oxide of titanium, with its primary occurrence observed specifically in rutile ores. This titanium compound holds remarkable significance in various technological realms, functioning as a commodity chemical extensively harnessed across diverse industries. In actuality, a substantial majority of titanium ores undergo processing procedures to yield Titanium Dioxide, consequently establishing its unrivaled status as the most extensively utilized titanium-based substance on a global scale.

Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.

Nanotoxicology “focuses on determining the adverse effects of nanomaterials on human health and the environment.”