It is suitable as an alternative to titanium dioxide when higher acid resistance is required, such as in adhesive joints and sealants. 

While loose titanium dioxide presents a problem, titanium dioxide within sunscreen formulations presents a much safer option than conventional sunscreen chemicals like oxybenzone and octinoxate. However, titanium dioxide may become dangerous when it is nanoparticle size. Generally, nanoparticles can be 1000 times smaller than the width of a human hair. Despite nanoparticles becoming increasingly common across industries, they have not been properly assessed for human or environmental health effects, nor are they adequately regulated. Researchers don’t quite understand the impacts nanoparticles could have on human health and the environment. However, because of their infinitesimally small size, nanoparticles may be more chemically reactive and therefore more bioavailable, and may behave differently than larger particles of the same substance; these characteristics may lead to potential damage in the human body or ecosystem.

Respiratory Exposure 

Relative to a lot of other things that people should be concerned about, titanium dioxide in my mind, is really low on the list. I would be more worried about some substitutes that people are using for titanium dioxide that don't have decades of research associated with it, said Westerhoff.