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One of the main applications of titanium dioxide in paper is in the production of high-quality coated papers. Titanium dioxide is often added to the coating formulations to enhance the whiteness and brightness of the paper surface. This helps to improve the print quality of the paper, as it provides a smooth and even surface for ink to adhere to. The high opacity of titanium dioxide also helps to prevent show-through, making the printed text or images more vibrant and legible.

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In 2021, the European Food Safety Authority concluded that titanium dioxide is no longer safe in foods due to the same concerns over nanoparticles. As a result, titanium dioxide is now banned as a food additive in the EU. Although studies have shown that the absorption of ingested titanium dioxide is low, evidence suggests that titanium dioxide nanoparticles can accumulate in the body over time. Health Canada deemed it safe in 2022 but noted concerns. Unlike their European counterparts, Canadian officials did not consider studies performed with titanium dioxide nanoparticles alone. 

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