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In conclusion, CAS 13463-67-7, representing 99% pure titanium dioxide powder, is an indispensable raw material pigment across multiple industries. Its versatility, combined with its exceptional optical and protective properties, has made it a go-to choice for formulators and manufacturers seeking to enhance the performance and aesthetics of their products. The bulk availability of this compound underscores its importance in meeting the demands of large-scale production, ensuring a reliable source for global industries.

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No acute effects of nano-sized TiO2 were observed in Danio rerio (zebrafish) embryos. Exposure of rainbow trout to TiO2 NPs triggered lipid peroxidation, influence on the respiratory tract, disturbance in the metabolism of Cu and Zn, induction of intestinal erosion  and accumulation in kidney tissue. Linhua et al. exposed juvenile carp to 100 and 200 mg/ml of particles and TiO2 observed no mortality. However, the fish suffered from oxidative stress and pathological changes in gill and liver. In the infaunal species Arenicola marina, exposure to TiO2 NPs in sediment caused sub-lethal effects including decrease in casting rate and increase in cellular and DNA damage. Aggregated particles were visible in the lumen of the gut, but no uptake through the gut or the skin was observed.

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