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The implementation of TIO2 technology in water factories is not without challenges. The efficient dispersion of TIO2 within water systems requires precise engineering to ensure maximum contact with contaminants The efficient dispersion of TIO2 within water systems requires precise engineering to ensure maximum contact with contaminants The efficient dispersion of TIO2 within water systems requires precise engineering to ensure maximum contact with contaminants The efficient dispersion of TIO2 within water systems requires precise engineering to ensure maximum contact with contaminantstio2 in water factory. Additionally, the current reliance on UV light to activate TIO2 necessitates the development of alternative activation methods to broaden its application in various settings.

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Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.

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