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Titanium dioxide (TiO2) is a naturally occurring mineral that is mined from the earth, processed and refined, and added to a variety of foods, as well as other consumer products. White in color, it is used to enhance the color and sheen of certain foods and is also key for food safety applications. In its natural state it exists in different bulk crystalline forms, such as anatase and rutile, but during processing it is ground into a very fine powder.

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Another approach utilizes titrimetry, where a standard solution of a titrant, such as lead perchlorate or barium perchlorate, is used to react with the sulfate ions. The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titratordetermination of sulphate as tio2. The volume of titrant used corresponds to the concentration of sulfate in the sample. Again, a stoichiometric calculation converts this to TiO2 content.

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In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

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