titanium dioxide in water factory
no evidence of cancer or other adverse effects in mice and rats exposed to high concentrations of food-grade TiO2 (long-term or lifetime study)
Potential Risks of Using Titanium Dioxide
Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.[1]
