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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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In conclusion, paint pigment factories are more than just manufacturing plants; they are the crucibles of color, where science and art intertwine to create the palette of our world. They symbolize the fusion of technology and creativity, playing a crucial role in shaping the visual aesthetics of our society. From the subtle shades of a Monet canvas to the bold hues of a modern skyscraper, the work of these factories is ever-present, often unnoticed but always essential.

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