While the conclusions of the EU expert panel were considered in this report, Health Canada's Food Directorate conducted its own comprehensive review of the available science. This included evaluating new scientific data that addressed some of the uncertainties identified by the EU expert panel and were not available at the time of their review.    

Here, NaOH or NH3 · H2O is used as a precipitant or pH regulator to react with FeSO4 to form ferrous hydroxide precipitation; Air is used as oxidant; The iron sheet reacts with sulfuric acid produced during the oxidative hydrolysis of FeSO4 to provide ferrous ions required in the reaction system and maintain the pH value of the solution. The alkali consumption of acid method is less and the particles are easy to wash. The relative rates of seed preparation and crystal growth determine the particle size, particle size distribution and particle morphology of iron yellow particles.

A review published in 2022 in the journal NanoImpact evaluated the latest research related to genotoxic effects of titanium dioxide through in vivo studies and in vitro cell tests. Researchers summarized the results by stating TiO2 nanoparticles “could induce genotoxicity prior to cytotoxicity,” and “are likely to be genotoxic to humans.”