On the other hand, the U.S. Food and Drug Administration (FDA) in their Final Administrative Order on Sunscreen Drug Products posted in September 2021 still accepts titanium dioxide up to 25% in the list of Generally Recognized As Safe and Effective (GRASE) in the main document, without further clarification on what kind or size of particles [9]. However, on page 24 (Sunscreen containing nanomaterials) FDA clearly “distinguish nanomaterials from other forms of these ingredients'' (zinc oxide and titanium dioxide) and ask for comments on “any particular nanomaterials that you believe should not be permitted for use in OTC sunscreen products”. To the best of our knowledge, this Agency did not ban the use of nanoparticulate titanium dioxide in any form, even though it is mentioned on page 34 that the anatase form is the more photoactive one, due to the lack of evidence with real sunscreens OTC (over the counter) in vivo. Moreover, other regulations in Latin America (MERCOSUR agreement, 2006) do not state clearly their position on the use of nanoparticulate TiO₂NPs [10].

In 2017, the Scientific Committee on Consumer Safety (SCCS) warned that they should revise their recommendations if any new evidence emerges in the future related to the potentially harmful effects of TiO₂NPs used in a sunscreen formulation or if they can penetrate the skin. In fact, our work could contribute to this matter because it evaluated the skin penetration of a particular kind of TiO₂NPs. [8]

In conclusion, as a leading manufacturer of nano titanium dioxide, we are proud to offer high-quality products that meet the needs of our customers in a wide range of industries. With our focus on strength, UV resistance, and optical properties, our nano titanium dioxide products are sure to enhance the performance and appearance of a variety of applications. Customers can trust in our commitment to sustainability and environmental responsibility, knowing that they are getting a product that is not only top quality but also eco-friendly.