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In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

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In vitro, in the hemocytes of the marine mussel Mytilus hemocytes, suspension of TiO2 NPs (Degussa P25, 10 μg/ml) stimulated immune and inflammatory responses, such as lysozyme release, oxidative burst and nitric oxide production. Vevers and Jha demonstrated the intrinsic genotoxic and cytotoxic potential of TiO2 NPs on a fish-cell line derived from rainbow-trout gonadal tissue (RTG-2 cells) after 24 h of exposure to 50 μg/ml. Reeves et al. demonstrated a significant increase in the level of oxidative DNA damage in goldfish cells, and suggested that damage could not repaired by DNA repair mechanisms. Another suggestion from the mentioned study was that hydroxyl radicals are generated also in the absence of UV light. It has been shown that fish cells are generally more susceptible to toxic/oxidative injury than mammalian cells.

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For instance, the development of waterborne coatings, a shift from traditional solvent-based systems, is a testament to the industry's commitment to reducing environmental impact. These manufacturers also work on enhancing the durability and performance of coatings, ensuring they can withstand harsh conditions and extend the lifespan of the coated surfaces These manufacturers also work on enhancing the durability and performance of coatings, ensuring they can withstand harsh conditions and extend the lifespan of the coated surfaces These manufacturers also work on enhancing the durability and performance of coatings, ensuring they can withstand harsh conditions and extend the lifespan of the coated surfaces These manufacturers also work on enhancing the durability and performance of coatings, ensuring they can withstand harsh conditions and extend the lifespan of the coated surfacescoating raw material manufacturer.

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