In a 2020 study published in the Journal of Trace Elements in Medicine and Biology, researchers conducted an in vitro experiment to analyze the effects of TiO2 nanoparticles on a human neuroblastoma (SH-SY5Y) cell line. The scientists evaluated “reactive oxygen species (ROS) generation, apoptosis, cellular antioxidant response, endoplasmic reticulum stress and autophagy.” The results showed that exposure to the nanoparticles “induced ROS generation in a dose dependent manner, with values reaching up to 10 fold those of controls. Nrf2 nuclear localization and autophagy also increased in a dose dependent manner. Apoptosis increased by 4- to 10-fold compared to the control group, depending on the dose employed.” 

Three aspects determine the performance of titanium dioxide as pigment and UV absorber.

Par ailleurs, dès lors que l'on recherche une certain transparence dans les travaux artistiques, son pouvoir opacifiant et son pouvoir dégradant des couleurs pas trop élevés le désignent pour remplacer le dioxyde de titane trop opaque et trop dégradant (§ Des Liants et des couleurs aux éditions EREC)

Ultimately, it comes down to whether you want to take the risk of having Titanium Dioxide in your blood stream?

We have long been passionate about avoiding exposure to Titanium Dioxide & are proud that our products offer a safe alternative to Women everywhere. We strongly urge you to ditch your toxic, unsafe makeup & find a safer alternative.

In the paper industry, art painting supplies level, use as a white opaque pigment for a variety of printing paper filler, white pigment for pencils, watercolors, art painting.