lomon r996

Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

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One of the main concerns about TiO2 in water supplies is the potential for nanoparticles to leach into drinking water sources from consumer products that contain TiO2, such as sunscreen and toothpaste. While the concentration of TiO2 in these products is typically low, there is still a risk of exposure through ingestion or inhalation While the concentration of TiO2 in these products is typically low, there is still a risk of exposure through ingestion or inhalation While the concentration of TiO2 in these products is typically low, there is still a risk of exposure through ingestion or inhalation While the concentration of TiO2 in these products is typically low, there is still a risk of exposure through ingestion or inhalationtio2 in water suppliers.

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