Titanium dioxide R-5566 can be widely used in indoor and outdoor coatings, latex paints, powder coatings, inks, papermaking, rubber, plastics, masterbatches.
In addition to the toxic effects of TiO2 NPs, discussed in previous chapters, these NPs have been also shown to promote photosynthesis and nitrogen metabolism, resulting in the enhanced growth of spinach. It increases the absorption of light and accelerates the transfer and transformation of the light energy. It was also found that treatment with nano-sized TiO2 significantly increased the level of antioxidant enzymes, and decreased the ROS accumulation and malonyldialdehyde content in spinach chloroplasts under visible and UV irradiation. TiO2 NPs also increased the superoxide dismutase activity of germinating soybean, enhanced its antioxidant ability, and promoted seed germination and seedling growth.
The concern from animal studies is that high amounts of titanium dioxide have increased inflammation and colon tumor formation, said Dr. Johnson-Arbor. A 2021 review, meanwhile, suggested that using titanium dioxide as a food additive weakens the gut lining and worsens the progression of inflammatory bowel disease.
Suppliers in this field must comply with strict pharmacopeia guidelines and often offer custom formulations to meet specific therapeutic requirements Suppliers in this field must comply with strict pharmacopeia guidelines and often offer custom formulations to meet specific therapeutic requirementssodium bicarbonate powder suppliers.In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2. With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”