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Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

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The refractive index of rutile TiO2 is among the highest known, which results in unparalleled hiding power in paints and coatings. Its ability to reflect light across a broad spectrum enhances the brightness and opacity of products, thereby reducing the amount of pigment required to achieve the desired effect. Consequently, rutile is frequently chosen over other types of TiO2 in industrial applications where high performance and cost efficiency are paramount.

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