Both P25TiO2NPs (with or without vitamin B2) were not found beyond the epidermis in 99% of the analyzed TEM images (Fig. 8). This is coherent with previous findings showing that nanoparticles greater than 50 nm can not penetrate the skin, even in vivo models with movement, stretching, and friction [54]. However, in one of the zones, a few nanoparticles were observed inside a hair follicle. This could be due to the follicle exposure after the localized rupture of this physical barrier when rats were shaved in order to clean the area for cream topical administration. This finding suggests that nanoparticle-based sunscreen should not be applied on recently shaved or harmed skin, in order to avoid nanoparticle skin penetration.
Moreover, the coatings formulated with MBR9668 exhibit excellent thermal stability, allowing them to perform well in various temperature ranges without compromising their consistency or effectiveness. This feature is particularly valuable in industries such as aerospace and manufacturing, where components must withstand extreme conditions.
This makes it an excellent choice for applications where weight and size are critical factors, such as in aerospace and transportation industries This makes it an excellent choice for applications where weight and size are critical factors, such as in aerospace and transportation industries
