In the context of titanium dioxide determination, the process generally begins with the sample preparation, where a known mass of the sample containing TiO2 is dissolved or digested appropriately. The subsequent steps involve adding a precipitating agent, such as ammonium sulfate or sulfuric acid, to the prepared solution, which facilitates the formation of a titanium precipitate. This precipitate is often titanium hydroxide, which is not only insoluble but can be easily filtered out from the liquid phase.

Below 20% substitution, it is recommended to replace 1 kg of TiO2 with 1 kg of Lithopone.  

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But a chemical’s safety when it’s used externally is not always the same as when it’s ingested. Different uses of the same ingredient may cause very different health outcomes.