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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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China's dominance in the titanium dioxide market is a testament to its robust industrial infrastructure and advanced chemical processing capabilities. According to industry reports, China accounts for more than half of the global titanium dioxide production, making it the largest producer and exporter of this pigment worldwide. This is largely due to the country's abundant reserves of titanium-bearing minerals, such as ilmenite and rutile, which are the primary raw materials for TiO2 production.

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