The evidence also suggests that the toxicity of TiO₂ particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO₂ particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.

While Skittles don't include white in their line-up, Dr. Johnson-Arbor theorizes that titanium dioxide is used to help contain all the other beautiful colors.