transparent titanium dioxide supplier

For research published in 2022 study in the journal Food and Chemical Toxicology, scientists examined “the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different TiO2 nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells, while considering the potential influence of the digestion process in the NMs’ physiochemical characteristics.” They found a “DNA-damaging effect dependent on the nanomaterial,” along with the micronucleus assay suggesting “effects on chromosomal integrity, an indicator of cancer risk, in the HT29-MTX-E12 cells, for all the tested TiO2 nanomaterials.” Researchers concluded that the results showcase “evidence of concern” regarding titanium dioxide used as a food additive.

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This constant high rate of ROS production leads rapidly to extreme macromolecular oxidation, here it is observed in the AOPP and MDA detected after 3 h in samples treated with bare P25TiO2NPs (Fig. 6Fig. 7). Macromolecular oxidation includes, among others, both protein and lipid oxidation. The ROS causes protein oxidation by direct reaction or indirect reactions with secondary by-products of oxidative stress. Protein fragmentation or cross-linkages could be produced after the oxidation of amino acid side chains and protein backbones. These and later dityrosine-containing protein products formed during excessive production of oxidants are known as advanced oxidation protein products (AOPP). They absorb at 340 nm and are used to estimate the damage to structural cell amino acids. Lipid oxidation is detected by the conjugation of oxidized polyunsaturated lipids with thiobarbituric acid, forming a molecule that absorbs light at 532 nm. Polyunsaturated lipids are oxidized as a result of a free-radical-mediated chain of reactions. The most exposed targets are usually membrane lipids. The macromolecular damage could represent a deadly danger if it is too extensive, and this might be the case. Moreover, it could be observed that cellular damage continues further and becomes irrevocable after 6 h and MDA could not be detected. This may be due to the fact that the lipids were completely degraded and cells were no longer viable. Lipids from the cell membrane are the most prone to oxidation. In fact, lipid peroxidation biomarkers are used to screen the oxidative body balance [51]. At the same time, AOPP values are up to 30 times higher for bare nanoparticles in comparison to the functionalized ones.

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  • Recent policy changes in regard to titanium dioxide

  • 4. Paper Lithopone is also used in the paper industry as a coating pigment, providing excellent brightness, opacity, and printability.
  • Preservatives are additives that extend the shelf life of food products, preventing spoilage due to microbial growth or oxidation. Common preservatives, such as sodium benzoate and potassium sorbate, are prevalent in processed foods. While these substances help maintain food safety and quality, some studies have raised alarms about potential health risks. Certain preservatives have been linked to allergic reactions, hormone disruption, and possibly even neurological issues.


  • E322 is widely used across various industries. In the food sector, it is found in baked goods, chocolates, margarine, dressings, and sauces. Lecithin helps improve the texture of these products, enhances shelf life, and imparts a desirable mouthfeel. For instance, in chocolate production, lecithin reduces viscosity, making the chocolate smoother and easier to process.


  • The combination of magnesium hydroxide and aluminum hydroxide presents a multifaceted approach to managing gastrointestinal discomfort while providing additional benefits in agricultural applications. Their synergistic relationship not only maximizes the therapeutic effects but also opens doors for innovative solutions in healthcare and agriculture. As research continues to explore these compounds, their potential will likely expand, offering improved health and wellness solutions for diverse populations.


  • Functions of PGPR in Food Products


  • Sodium Benzoate in China An Overview


  • Another point of discussion is the potential impact of maltodextrin on gut health. Some studies suggest that it may promote the growth of certain harmful bacteria in the gut, potentially leading to intestinal distress in sensitive individuals. As with many food additives, moderation is key, and it is essential for consumers to read labels and understand the contents of the products they consume.