The integrity of surface skin cells was evaluated with and without solar simulated irradiation. The integrity of the stratum corneum was significantly lower in individuals treated with P25TiO₂NPs under the light in comparison to the ones that received the functionalized nanoparticles. Cell membrane suffering is evident (Fig. 9), and it is in accordance with the ROS levels and macromolecule oxidation found in vitro for the irradiated P25TiO₂NPs. Disruption of the superficial skin layer was observed in all animals treated with no functionalized nanoparticles, under irradiation. This data expands the findings by the group of Professors Fubini and Fenoglio, who showed that P25TiO₂NPs could impact the lipid structure at the top few microns of the stratum corneum [55]. Control skin under irradiation and without any topic formulation did not show changes in cell structure.

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Hebei Caiqing Material Technology Co., Ltd. was established in 2005 and has been at the forefront of chemical product research and development. Focusing on the field of titanium dioxide, the company has played a vital role in meeting global demand, providing personalized customization services to global customers. With the continuous expansion of the titanium dioxide market, Hebei Caiqing Material Technology Co., Ltd. is ready to meet the industry's growing demand in terms of production and service.

Titanium dioxide can amplify and brighten white opacity because of its exceptional light-scattering properties. In food and drugs, these properties help to define colors clearly and can prevent products from UV degradation. 

Titanium dioxide particles help light scatter and reflect, Kelly Johnson-Arbor, MD, a medical toxicology physician at the National Capital Poison Center, told Health. Because of that, we often use it as a whitening agent.