77891 titanium dioxide

Despite these advancements, challenges remain in translating laboratory findings into clinical practice. The biodistribution, biodegradation, and potential long-term effects of TiO2 in the human body need further investigation. However, China's commitment to research and development, coupled with its advanced manufacturing capabilities, positions the country well to overcome these hurdles and bring TiO2-based medical solutions to the global market.

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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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