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A 2022 review on past studies of titanium dioxide and rat lung cancer, for instance, said the original study was under extreme conditions and its effects were not replicated in other animal species. Additionally, the review concluded that the few studies which did directly focus on titanium dioxide's impact on humans did not end up showing any increased cancer risk.
Lithopone 30% is the perfect solution for partial substitution of TiO2 in fillers due to its very soft nature and hardly any shrinkage properties.