In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon. There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”
The author thanks Marco Leona, Scientist-in-Charge of the Department of Scientific Research at the Metropolitan Museum of Art for conducting fluorescence spectrometry on Wheel of Fortune and a valuable discussion of the research, as well as Silvia Centeno, Research Scientist at the Metropolitan Museum of Art, who performed Raman analysis on the watercolors and also contributed her insight. The phenomenon of the phosphorescing lithopone was originally discovered during the author's fellowship in the Sherman Fairchild Center for the Conservation of Works on Paper, funded by the Andrew W. Mellon Foundation. The author thanks all her colleagues for their ideas and support during the research of this paper, and special thanks to Rachel Mustalish for her assistance in editing this work.
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The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titrator The endpoint of the titration is determined either by a color change indicator or more sophisticated instrumentation like a potentiometric titratordetermination of sulphate as tio2. The volume of titrant used corresponds to the concentration of sulfate in the sample. Again, a stoichiometric calculation converts this to TiO2 content.While Skittles don't include white in their line-up, Dr. Johnson-Arbor theorizes that titanium dioxide is used to help contain all the other beautiful colors.