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In conclusion, China's titanium dioxide industry, while contributing significantly to the economy, is also confronted with the challenge of sustainable water management. The combination of strict regulations, technological innovation, and green chemistry initiatives is shaping the future of this sector, ensuring responsible production and the preservation of water resources. As the industry continues to evolve, it is crucial to maintain a balance between economic growth and environmental protection, harnessing the potential of TiO2 for both industrial use and environmental remediation.

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The National Cancer Institute tested TiO2 for possible carcinogenicity by the oral route of exposure by feeding rats and mice with TiO2 (size not specified) at doses 25,000 or 50,000 ppm TiO2 for 103 weeks. They concluded that TiO2 was not carcinogenic.Also, the study with rats fed diets containing up to 5 % TiO2 coated mica for 130 weeks showed no treatment-related carcinogenicity. Since the size and other TiO2 properties were not specified or determined, we cannot generalize this conclusion and we have to take into account other possible outcomes of this scenario in different exposure conditions (other size/crystalline structure of TiO2 etc.).

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