In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

Example of partial substitution of titanium dioxide with lithopone supplier 30% in a white masterbatch 

Reasons for listing: Sichuan Lomon Group Co., Ltd., a well-known brand of titanium dioxide, a famous trademark in Sichuan, a famous brand in Sichuan, a state-recognized enterprise technology center, one of the largest titanium dioxide manufacturers in China, phosphorous chemical, titanium chemical, biochemical It is a large-scale private enterprise group integrating the comprehensive development and utilization of vanadium titanomagnetite.

The gastrointestinal tract is a complex barrier/exchange system, and is the most important route by which macromolecules can enter the body. The main absorption takes place through villi and microvilli of the epithelium of the small and large intestines, which have an overall surface of about 200 m². Already in 1922, it was recognized by Kumagai, that particles can translocate from the lumen of the intestinal tract via aggregation of intestinal lymphatic tissue (Peyer’s patch, containing M-cells (phagocytic enterocytes)). Uptake can also occur via the normal intestinal enterocytes. Solid particles, once in the sub-mucosal tissue, are able to enter both the lymphatic and blood circulation.