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Furthermore, TiO2 is a versatile and environmentally friendly pigment that is widely used in the paper industry. It is non-toxic, biologically inert, and poses no harm to human health or the environment. As sustainability and eco-friendliness become increasingly important considerations for consumers, paper suppliers are turning to TiO2 as a safe and responsible choice for enhancing the quality of their products. TiO2 is also recyclable, making it a sustainable option for paper manufacturers looking to reduce their environmental footprint.

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As mentioned above, these oxide NPs are harmful in part because both anatase and rutile forms are semiconductors and produce ROS. Particularly, P25 kind has band-gap energies estimated of 3.2 and 3.0 eV, equivalent to radiation wavelengths of approximately 388 and 414 nm, respectively. Irradiation at these wavelengths or below produces a separation of charge, resulting in a hole in the valence band and a free electron in the conduction band, due to the electron movement from the valence to conduction bands. These hole–electron pairs generate ROS when they interact with H2O or O2 [43,44]. It was described that they can cause an increase in ROS levels after exposure to UV-visible light [45]. The NBT assay in the studied samples showed that bare P25TiO2NPs produce a large amount of ROS, which is drastically reduced by functionalization with vitamin B2 (Fig. 5). This vitamin, also known as riboflavin, was discovered in 1872 as a yellow fluorescent pigment, [46] but its function as an essential vitamin for humans was established more than sixty years later, and its antioxidant capacity was not studied until the end of the XX century [47,48]. This antioxidant role in cells is partially explained because the glutathione reductase enzyme (GR) requires it for good functionality. This enzyme is the one in charge of the conversion of oxidized glutathione to its reduced form which acts as a powerful inner antioxidant and can quench the ROS [49,50]. The cost of this action is that the glutathione is converted to the oxidized form and needs to be recovered by the GR. Consequently, the cells need more vitamin B2. Another glutathione action is the protection against hydroperoxide. This activity is also mediated by riboflavin. Therefore, local delivery of this vitamin seems to significantly help the cells in their fight to keep the oxidative balance, once they are exposed to high levels of ROS.

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In conclusion, titanium dioxide is a versatile and widely used ingredient in the cosmetics industry. Its benefits include broad-spectrum sun protection, natural pigmentation, chemical stability, and non-irritating properties. While there are some safety concerns regarding its use, regulatory agencies have established guidelines to ensure its safe use in cosmetic products. As the demand for natural and safe cosmetic products continues to grow, the future outlook for TiO2 in the cosmetics industry looks promising.

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