cas no. 13463-67-7

3. Tronox Limited Tronox Limited is a leading producer of titanium dioxide and other mineral products. The company operates several production facilities globally and offers a wide range of TiO2 products, including rutile, anatase, and speciality grades The company operates several production facilities globally and offers a wide range of TiO2 products, including rutile, anatase, and speciality grades The company operates several production facilities globally and offers a wide range of TiO2 products, including rutile, anatase, and speciality grades The company operates several production facilities globally and offers a wide range of TiO2 products, including rutile, anatase, and speciality gradestio2 white manufacturers. Tronox Limited is committed to sustainability and has implemented several environmental initiatives to reduce its carbon footprint. The company also places a strong emphasis on safety and health, and has received numerous awards for its commitment to these areas.

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In a 2020 study published in the Journal of Trace Elements in Medicine and Biology, researchers conducted an in vitro experiment to analyze the effects of TiO2 nanoparticles on a human neuroblastoma (SH-SY5Y) cell line. The scientists evaluated “reactive oxygen species (ROS) generation, apoptosis, cellular antioxidant response, endoplasmic reticulum stress and autophagy.” The results showed that exposure to the nanoparticles “induced ROS generation in a dose dependent manner, with values reaching up to 10 fold those of controls. Nrf2 nuclear localization and autophagy also increased in a dose dependent manner. Apoptosis increased by 4- to 10-fold compared to the control group, depending on the dose employed.” 

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