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The neuromorphic nature of the resistive switching in TiO2 memristors has triggered a series of studies addressing their functional coupling with living biological systems. The common features of the electroconductive behavior of memristive and biological neural networks have been revised in terms of physical, mathematical, and stochastic models (Chua, 2013Feali and Ahmadi, 2016). The memristive electronics was shown to support important synaptic functions such as spike timing-dependent plasticity (Jo et al., 2010Pickett et al., 2013). Recently, a memristive simulation of important biological synaptic functions such as non-linear transmission characteristics, short-/long-term plasticity, and paired-pulse facilitation has been reported for hybrid organic–inorganic memristors using Ti-based maleic acid/TiO2 ultrathin films (Liu et al., 2020). In relation to this, functionalized TiO2 memristive systems may be in competition with the new generation of two-dimensional memristive materials such as WSe2 (Zhu et al., 2018), MoS2 (Li et al., 2018), MoS2/graphene (Kalita et al., 2019), and other systems (Zhang et al., 2019a) with ionic coupling, ionic modulation effects, or other synapse-mimicking functionalities. Furthermore, the biomimetic fabrication of TiO2 (Seisenbaeva et al., 2010Vijayan and Puglia, 2019Kumar et al., 2020) opens up new horizons for its versatile microstructural patterning and functionalizations.

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Despite these concerns, the use of TiO2 in food manufacturing continues to grow. This is largely due to its effectiveness as a whitening agent and its low cost. Additionally, manufacturers have taken steps to ensure that TiO2 is used safely in their products. For example, they may use smaller particle sizes or encapsulate the TiO2 to reduce its potential for inhalation or ingestion For example, they may use smaller particle sizes or encapsulate the TiO2 to reduce its potential for inhalation or ingestion For example, they may use smaller particle sizes or encapsulate the TiO2 to reduce its potential for inhalation or ingestion For example, they may use smaller particle sizes or encapsulate the TiO2 to reduce its potential for inhalation or ingestionfood safe titanium dioxide factory.

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