The evidence also suggests that the toxicity of TiO₂ particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO₂ particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.

But despite all these cries of alarm, five years on from the original study no further testing into the safety of Titanium Dioxide in our food supply

THE OBSCURE HISTORY OF A UBIQUITOUS PIGMENT: PHOSPHORESCENT LITHOPONE AND ITS APPEARANCE ON DRAWINGS BY JOHN LA FARGE

Calcium carbonate is a naturally occurring mineral that is found in rocks and minerals such as calcite, aragonite, and limestone. It is commonly used in industries such as paint, paper, plastics, and rubber as a filler and pigment. The manufacturing process of calcium carbonate involves extracting the mineral from quarries or mines, crushing and grinding it into a fine powder, and then purifying it through various chemical processes.