There are many titanium dioxide manufacturer in market. Rutile Titanium dioxide in the form of a white pigment is widely used in the industry:
1. In the production of inks and printing inks - as a pigment with excellent whiteness and very good properties.
2. Plastic materials, such as: wall claddings, floor coverings (linoleum, rubber, PVC), roofing, wires, cables - titanium white is included in the protective layer against degradation of atmospheric conditions (especially UV radiation), and has concealing properties.
3. Cosmetics: gels, eye shadows, foundation, lipstick, pastes (including teeth) - as a component of pigments.
4. Tanning preparations - surface-modified with a hydrophobic coating - acts as a UV filter.
5. Paper pulp - anatine is used as a filler and reinforcement.
6, Packaging film, adhesive mortars, plasters, cement, caulking agents, ceramic tiles - is an additive that improves resistance to colour change.
7. PCigar production - titanium white gives the ash a white color.

Stability and darkening

6.0-8.0

Still many experts say the body of research does not support the current health concerns being expressed about titanium dioxide.

Duan et al. administered 125 mg/kg BW or 250 mg/kg BW of anatase TiO₂ (5 nm) intragastrically to mice continuously for 30 days. The exposed mice lost body weight, whereas the relative liver, kidney, spleen and thymus weights increased. Particles seriously affected the haemostasis of the blood and the immune system. The decrease in the immune response could be the result of damage to the spleen, which is the largest immune organ in animals and plays an important role in the immune response. Powel et al. demonstrated that TiO₂ NPs may trigger immune reactions of the intestine after oral intake. They showed that TiO₂ NPs conjugated with bacterial lipopolysaccharide, but not TiO₂ NPs or lipopolysaccharide alone, trigger the immune response in human peripheral blood mononuclear cells and in isolated intestinal tissue. This indicates that TiO₂ NPs may be important mediators in overcoming normal gut-cell hyporesponsiveness to endogenous luminal molecules, which may be particularly relevant to patients with inflammatory bowel disease, which is characterized by an abnormal intestinal permeability.

Titanium dioxide (TiO2) is a versatile and widely used inorganic compound that has numerous applications, ranging from pigments in paints and coatings to cosmetics and pharmaceuticals. As a result, the demand for TiO2 powder suppliers has been steadily increasing.

As mentioned above, these oxide NPs are harmful in part because both anatase and rutile forms are semiconductors and produce ROS. Particularly, P25 kind has band-gap energies estimated of 3.2 and 3.0 eV, equivalent to radiation wavelengths of approximately 388 and 414 nm, respectively. Irradiation at these wavelengths or below produces a separation of charge, resulting in a hole in the valence band and a free electron in the conduction band, due to the electron movement from the valence to conduction bands. These hole–electron pairs generate ROS when they interact with H₂O or O₂ [43,44]. It was described that they can cause an increase in ROS levels after exposure to UV-visible light [45]. The NBT assay in the studied samples showed that bare P25TiO₂NPs produce a large amount of ROS, which is drastically reduced by functionalization with vitamin B2 (Fig. 5). This vitamin, also known as riboflavin, was discovered in 1872 as a yellow fluorescent pigment, [46] but its function as an essential vitamin for humans was established more than sixty years later, and its antioxidant capacity was not studied until the end of the XX century [47,48]. This antioxidant role in cells is partially explained because the glutathione reductase enzyme (GR) requires it for good functionality. This enzyme is the one in charge of the conversion of oxidized glutathione to its reduced form which acts as a powerful inner antioxidant and can quench the ROS [49,50]. The cost of this action is that the glutathione is converted to the oxidized form and needs to be recovered by the GR. Consequently, the cells need more vitamin B2. Another glutathione action is the protection against hydroperoxide. This activity is also mediated by riboflavin. Therefore, local delivery of this vitamin seems to significantly help the cells in their fight to keep the oxidative balance, once they are exposed to high levels of ROS.

Food additive nanoparticles could negatively affect your gut health, by Jillian McCarthy, Binghamton University, May 4, 2023