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The integrity of surface skin cells was evaluated with and without solar simulated irradiation. The integrity of the stratum corneum was significantly lower in individuals treated with P25TiO2NPs under the light in comparison to the ones that received the functionalized nanoparticles. Cell membrane suffering is evident (Fig. 9), and it is in accordance with the ROS levels and macromolecule oxidation found in vitro for the irradiated P25TiO2NPs. Disruption of the superficial skin layer was observed in all animals treated with no functionalized nanoparticles, under irradiation. This data expands the findings by the group of Professors Fubini and Fenoglio, who showed that P25TiO2NPs could impact the lipid structure at the top few microns of the stratum corneum [55]. Control skin under irradiation and without any topic formulation did not show changes in cell structure.

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In conclusion, CAS 13463-67-7, representing 99% pure titanium dioxide powder, is an indispensable raw material pigment across multiple industries. Its versatility, combined with its exceptional optical and protective properties, has made it a go-to choice for formulators and manufacturers seeking to enhance the performance and aesthetics of their products. The bulk availability of this compound underscores its importance in meeting the demands of large-scale production, ensuring a reliable source for global industries.

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