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The trend in the production of NPs is likely to lead to increasing amounts of nano-powders in the air, water and soil, which will consequently affect living organisms. Labielle et al. demonstrated that 25 % of Al(OH)3-coated TiO2 particles from sunscreens are dispersed as a stable colloid and become available to microorganisms and filter-feeders, while the remaining 75 % are probably incorporated into geogenic sediments, where they could become available to benthic fauna. Solar UV iradiation may penetrate as far as 20 m in the water column  and therefore photo-activate the dispersed particles, which may have an adverse effect on various aquatic organisms.

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Despite these advancements, challenges remain in translating laboratory findings into clinical practice. The biodistribution, biodegradation, and potential long-term effects of TiO2 in the human body need further investigation. However, China's commitment to research and development, coupled with its advanced manufacturing capabilities, positions the country well to overcome these hurdles and bring TiO2-based medical solutions to the global market.

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