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Moreover, with increasing concerns over sustainability, TIO2 pigment manufacturers are under pressure to develop more eco-friendly production methods. This includes recycling waste streams, using renewable energy sources, and reducing the carbon footprint associated with the extraction and processing of titanium ore This includes recycling waste streams, using renewable energy sources, and reducing the carbon footprint associated with the extraction and processing of titanium ore This includes recycling waste streams, using renewable energy sources, and reducing the carbon footprint associated with the extraction and processing of titanium ore This includes recycling waste streams, using renewable energy sources, and reducing the carbon footprint associated with the extraction and processing of titanium oretio2 pigment manufacturers. Some companies have even turned to synthetic biology to produce TIO2 pigments through microorganisms, aiming to create a bio-based alternative to traditional mining and chemical synthesis.

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Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

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