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Firstly, it's essential to understand what makes lithopone a preferred choice for many consumers. Unlike traditional lead-based paints, lithopone is free from harmful substances, making it an environmentally friendly option. Its superior coverage means that fewer coats are needed to achieve the desired finish, which translates to cost savings for homeowners and contractors alike. Moreover, lithopone's brightness index is higher than most pigments, ensuring a vibrant and long-lasting appearance on walls.

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Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.

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