china anatase titanium dioxide pigment price
In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2. With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”
Rutile, also known as titanium oxide (TiO2), is a hard, lustrous, and chemically inert mineral. It is composed of titanium and oxygen atoms and has a tetragonal crystal structure. Rutile is characterized by its high refractive index, high melting point, and excellent electrical conductivity. These properties make it an ideal material for a wide range of applications, including pigments, coatings, plastics, ceramics, and electronics.
Cristal Global Holdings Ltd., a major producer of titanium dioxide, prides itself on operational excellence and a strong global presence. Their focus on quality and customer satisfaction has earned them a respected position in the market.
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Additional Health Concerns Linked to Titanium Dioxide
In the paint industry, China's demand for TiO2 has been steadily increasing over the years. With the country's booming construction industry and growing automotive sector, the need for high-quality paints that provide long-lasting color and protection has also risen. TiO2 is a key ingredient in paints as it helps to improve the coverage and durability of the paint, making it resistant to fading and weathering.
Growing use of Lithopone in the plastics processing industry
The primary function of Anatase Titanium Dioxide in food is as a coloring agent. Its intense whiteness can effectively brighten and whiten foods such as powdered sugar, confectionery, and dairy products. By adding small amounts of this compound, manufacturers can achieve a more visually appealing product that attracts consumers. Moreover, its high refractive index means that it can be used to add a glossy finish to certain foods, further enhancing their appeal.
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2025-08-14 22:56
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In a review published in 2022 in the journal Archives of Toxicology, researchers found that the ingestion of E171 is a “a definite health risk for consumers and their progeny.” After reviewing dozens of in vivo, ex vivo and in vitro studies on the toxicity of E171, the researchers wrote that two facts must be noted: “First, reprotoxicity studies show that animals of both sexes are impacted by the toxicity of these nanoparticles, underlining the importance of conducting in vivo studies using both male and female animals. Second, human exposure begins in utero via maternal-fetal transfer and continues after birth by breastfeeding. Children are then chronically re-exposed due to their food preferences. To be relevant to the human in vivo situation, experimental studies should therefore consider nanoparticle exposure with respect to the age or life period of the studied population.”
As mentioned above, these oxide NPs are harmful in part because both anatase and rutile forms are semiconductors and produce ROS. Particularly, P25 kind has band-gap energies estimated of 3.2 and 3.0 eV, equivalent to radiation wavelengths of approximately 388 and 414 nm, respectively. Irradiation at these wavelengths or below produces a separation of charge, resulting in a hole in the valence band and a free electron in the conduction band, due to the electron movement from the valence to conduction bands. These hole–electron pairs generate ROS when they interact with H2O or O2 [43,44]. It was described that they can cause an increase in ROS levels after exposure to UV-visible light [45]. The NBT assay in the studied samples showed that bare P25TiO2NPs produce a large amount of ROS, which is drastically reduced by functionalization with vitamin B2 (Fig. 5). This vitamin, also known as riboflavin, was discovered in 1872 as a yellow fluorescent pigment, [46] but its function as an essential vitamin for humans was established more than sixty years later, and its antioxidant capacity was not studied until the end of the XX century [47,48]. This antioxidant role in cells is partially explained because the glutathione reductase enzyme (GR) requires it for good functionality. This enzyme is the one in charge of the conversion of oxidized glutathione to its reduced form which acts as a powerful inner antioxidant and can quench the ROS [49,50]. The cost of this action is that the glutathione is converted to the oxidized form and needs to be recovered by the GR. Consequently, the cells need more vitamin B2. Another glutathione action is the protection against hydroperoxide. This activity is also mediated by riboflavin. Therefore, local delivery of this vitamin seems to significantly help the cells in their fight to keep the oxidative balance, once they are exposed to high levels of ROS.